Evidence map›Paper›PMID 42521805›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2026

First-harmonic attenuation of radial pulse waves as a sensitive marker for vascular aging.

Yu-Cheng Kuo, Quan Zhang, Po-Jen Shih

Abstract read
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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu-Cheng KuoDepartment of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Quan ZhangMass General Research Institute, Harvard Medical School, Boston, MA, USA. qzhang@mgh.harvard.edu.
Po-Jen ShihDepartment of Biomedical Engineering, National Taiwan University, Taipei, Taiwan. pjshih@ntu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate assessment of vascular aging and arterial stiffness is essential for early cardiovascular intervention. Traditional pulse wave velocity (PWV) measurements often face limitations in peripheral arteries. This study proposes complex wave velocity derived from the radial pulse as a novel metric for evaluating age-related vascular changes. We performed radial pulse wave analysis on 919 participants (aged 6-92 years). Using a non-invasive pressure transducer, pulse waveforms were recorded and transformed into the frequency domain. A wave propagation model based on the Womersley number was applied to determine the real (X) and imaginary (Y) components of the complex wave speed for the first four harmonics. The first harmonic emerged as the dominant energy contributor with the highest measurement stability. Analysis of the vascular property revealed that the imaginary component (Y

Indexed as

AgingPulse Wave AnalysisRadial ArteryVascular StiffnessAdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedComplex wave velocityPulse wave harmonicsRadial pulse wave analysisVascular agingVascular property

Identifiers

PMID42521805

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.