Evidence map›Paper›PMID 42521793›Full record

ArticlePediatric research2026

Comparable lung injury with and without distal perfusion during aortic arch procedure in piglets.

Sabine Meier, Maja-Theresa Dieterlen, Christian Mühlfeld, Janine Schob, Kristin Klaeske, Susann Oßmann, Enrika Schütze, Mia Bovet, Michael A Borger, Martin Kostelka and 1 more

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Sabine Meier *University Clinic of Cardiac Surgery, HELIOS Clinic, University of Leipzig, Heart Center Leipzig, Leipzig, Germany.
Maja-Theresa Dieterlen *University Clinic of Cardiac Surgery, HELIOS Clinic, University of Leipzig, Heart Center Leipzig, Leipzig, Germany. mdieterlen@web.de.
Christian MühlfeldHannover Medical School, Institute of Functional and Applied Anatomy, Hannover, Germany.
Janine SchobHannover Medical School, Institute of Functional and Applied Anatomy, Hannover, Germany.
Kristin KlaeskeUniversity Clinic of Cardiac Surgery, HELIOS Clinic, University of Leipzig, Heart Center Leipzig, Leipzig, Germany.
Susann OßmannUniversity Clinic of Cardiac Surgery, HELIOS Clinic, University of Leipzig, Heart Center Leipzig, Leipzig, Germany.
Enrika SchützeUniversity Clinic of Cardiac Surgery, HELIOS Clinic, University of Leipzig, Heart Center Leipzig, Leipzig, Germany.
Mia BovetUniversity Clinic of Cardiac Surgery, HELIOS Clinic, University of Leipzig, Heart Center Leipzig, Leipzig, Germany.
Michael A BorgerUniversity Clinic of Cardiac Surgery, HELIOS Clinic, University of Leipzig, Heart Center Leipzig, Leipzig, Germany.
Martin KostelkaUniversity Clinic of Cardiac Surgery, HELIOS Clinic, University of Leipzig, Heart Center Leipzig, Leipzig, Germany.
Marcel VollrothUniversity Clinic of Cardiac Surgery, HELIOS Clinic, University of Leipzig, Heart Center Leipzig, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe reduction of pulmonary impairment due to complex aortic arch procedures in neonates and infants requires the most protective perfusion strategy during surgical intervention. We compared the selective anterograde cerebral perfusion (SACP) and SACP plus distal perfusion (SACP + DP) with moderate hypothermia in a piglet model with a focus on lung injury.

methodsSuckling piglets (2.5-10 kg) were randomized to undergo cross clamp for 60 min with either SACP (n = 9) or SACP + DP (n = 9) followed by 120 min of recovery. Lung tissue biopsies were analyzed for histological changes and the induction of hypoxia-related and pro-apoptotic factors.

resultsDifferences in body perfusion were proven by increased blood lactate levels (p = 0.01) and decreased oxygen saturation (p = 0.01) with SACP group compared to SACP + DP. The numbers of alveolar macrophages and type II pneumocytes (p = 0.39) as well as neutrophil profiles per area (p = 0.33) were similar in the SACP and SACP + DP group after 120 min of recovery. Stereological parameters of blood-air barrier damage and edema development were not different between both groups. Oxidative stress and the mitochondrial release of the pro-apoptotic molecules were similar in the SACP and the SACP + DP group.

conclusionOur piglet study demonstrated a similar degree of lung injury in SACP and SACP + DP during aortic arch procedures. IMPACT STATEMENT: SACP and SACP + DP during aortic arch surgery lead to a similar degree of lung injury in a piglet model. This prospective randomized comparison including histopathological and stereological analyses provides an objective evaluation of lung injury with different perfusion strategies. Clinical decision making for an optimal perfusion strategy in pediatric patients could be supported by the results of this study.

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PMID42521793

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