Evidence map›Paper›PMID 42521785›Full record

ArticleNPJ cardiovascular health2026

Proliferation dynamics of organotypic vascular endothelium during aging.

Yifang Mao, Anna Babin-Ebell Gonçalves, Lorna Rinck, Marlene Hoffarth, Gladys Hofsetz, Miki Kamiyama, Chi-Chung Wu, Junhao Hu, Mahak Singhal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ cardiovascular health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yifang Mao *AngioRhythms in Health and Disease, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Anna Babin-Ebell Gonçalves *AngioRhythms in Health and Disease, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Lorna RinckAngioRhythms in Health and Disease, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Marlene HoffarthAngioRhythms in Health and Disease, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Gladys HofsetzHelmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University, Heidelberg, Germany.
Miki KamiyamaAngioRhythms in Health and Disease, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Chi-Chung WuHelmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University, Heidelberg, Germany.
Junhao HuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Mahak SinghalAngioRhythms in Health and Disease, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. mahak.singhal@medma.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-7303-9585

Funding

Deutsche Forschungsgemeinschaft 394046768European Research Council 101220624
6 · The paper itself

Abstract

Healthy blood vessels are vital for organismal health. Blood vessel-lining endothelial cells (ECs) can self-replicate to maintain vascular homeostasis, yet the age-related dynamics of EC proliferation remain elusive. Employing cumulative labeling of proliferating ECs, we here present a temporal map of organotypic changes in endothelial proliferation at different stages of mouse life [juvenile (J), 1-month-old; young adult (YA), 4-month-old; old adult (OA), 14-month-old]. Comparative analyses of 12 different organs revealed a tissue-specific pattern of age-related changes in endothelial proliferation capacity. Contrary to the prevailing notion, the majority of analyzed vascular beds retained their proliferative capacity during aging. Intriguingly, lung ECs manifested increased proliferation, whereas adipose, colon, and liver tissues displayed reduced EC proliferation during aging. Together, the data provide a vascular reference framework, highlighting a high degree of organ specificity in the self-renewal capacity of differentiated ECs and uncovering the influence of organismal aging on EC proliferation.

Identifiers

PMID42521785
PMCPMC13415563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.