ArticleBritish journal of cancer2026
Spatial transcriptomics differences of histopathological growth patterns in colorectal cancer liver metastases.
Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHistopathological growth patterns (HGPs) have emerged as prognostic and predictive biomarkers in colorectal liver metastases (CLM). The desmoplastic/encapsulating HGP (EHGP) is associated with improved survival after surgery, whereas the replacement HGP (RHGP) is associated with poorer outcomes. However, HGPs can only be reliably assessed postoperatively, limiting their use as preoperative biomarkers. A deeper molecular understanding of HGPs could inform biomarker development and therapeutic strategies, including approaches to promote EHGP.
methodsWe applied in situ sequencing (ISS), an image-based spatial transcriptomics method, to map RNA expression in CLM tissue. Two custom gene panels (150 and 175 genes) were analysed in a chemonaïve cohort of resected CLM tissue from 19 patients with EHGP and RHGP.
resultsDistinct molecular programmes characterised the two patterns. RHGP was associated with damaged SAA1
conclusionsThese differences imply that growth patterns emerge from tumour-host driven interactions. They reveal new molecular features of the metastatic niche. These insights may inform the search for novel treatment strategies.
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