Evidence map›Paper›PMID 42521743›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Feasibility of lung ultrasound-guided positive end-expiratory pressure adjustment in newborns.

Anna Holst Møller, Christian Heiring, Sebastian Pornpakdee Feldskou, Katrin Klebermass-Schrehof, Mette Høj Lauridsen, Kasper Jacobsen Kyng

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna Holst MøllerDepartment of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark. annahm@live.dk.ORCID http://orcid.org/0009-0004-3398-172X
Christian HeiringDepartment of Neonatal and Pediatrics Intensive Care, Copenhagen University Hospital, Copenhagen, Denmark.
Sebastian Pornpakdee FeldskouDepartment of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
Katrin Klebermass-SchrehofDivision of Neonatology, Department of Pediatrics and Adolescent Medicine, Pediatric Intensive Care and Neuropediatrics, Medical University of Vienna, Vienna, Austria.
Mette Høj LauridsenDepartment of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-7299-0670
Kasper Jacobsen KyngDepartment of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate whether an ultrasound-guided lung recruitment manoeuvre (LRM) can identify a positive end-expiratory pressure (PEEP) associated with improved aeration compared with clinically set PEEP during non-invasive respiratory support. STUDY

designFeasibility study of 11 spontaneously breathing infants on continuous positive airway pressure or non-invasive ventilation. PEEP was increased stepwise by 2 cmH

resultsIn 10 of 11 infants (91%; 95% confidence interval 62-99, p = 0.01), the LRM identified a PEEP with a lower lung ultrasound score than the clinically set level; five infants required a higher and five a lower PEEP. Clinical parameters were stable or improved.

conclusionIn this pilot cohort, lung ultrasound-guided PEEP adjustment appeared feasible and was associated with favourable short-term changes in lung aeration. Larger studies are required to validate these preliminary findings and determine clinical utility.

Identifiers

PMID42521743

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.