Evidence map›Paper›PMID 42521605›Full record

ArticleEmerging infectious diseases2026

Doxycycline Resistance and 16S rRNA Mutations in Treponema pallidum.

Mathew A Beale, Michael Marks, Annie Luetkemeyer, Connie Celum, Matthew R Golden, Lorenzo Giacani, Nicole A P Lieberman

Abstract readLetter
In one paragraph

Article in Emerging infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mathew A Beale
Michael Marks
Annie Luetkemeyer
Connie Celum
Matthew R Golden
Lorenzo Giacani
Nicole A P Lieberman

Funding

Evaluation of doxycycline post-exposure prophylaxis to reduce sexually transmitted infections in PrEP users and HIV-infected men who have sex with menR01AI143439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CELUM, CONNIE L, LUETKEMEYER, ANNE FREY · 2019 to 2023
$8.3M
The Doxy-PEP Impact Study: a multi-city US longitudinal cohort to evaluate doxy-PEP field effectiveness, investigate associated antimicrobial resistance, and establish doxy-PEP to need ratiosR01AI181732 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CONNIE L CELUM, Anne Frey Luetkemeyer · 2024 to 2026
$4.6M
NIAID NIH HHS R01 AI143439NIAID NIH HHS R01 AI181732Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antimicrobial resistancebacteriasyphilisTreponema pallidum

Identifiers

PMID42521605
PMCPMC13426860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.