Evidence map›Paper›PMID 42521490›Full record

ArticleInternational journal of stem cells2026

A Cerebral Organoid Model of Familial Alzheimer's Disease Using Amyloid Precursor Protein Mutation, Val669Leu (

Won Hee Jung, Seung Tack Oh, Mu Seog Choe, Yu Jin Kwon, So Jin Kim, Ye Seong Jeon, Kyung Min Baek, Woochul Chang, Kyung Seob Lim, Joong Sun Kim and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Won Hee JungDepartment of Molecular Physiology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Vessel-Organ Interaction Research Center, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0009-0005-1593-7001
Seung Tack OhDepartment of Molecular Physiology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Vessel-Organ Interaction Research Center, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0009-0005-0682-6959
Mu Seog ChoeDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center (VOICE, MRC), Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-4826-895X
Yu Jin KwonDepartment of Molecular Physiology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Vessel-Organ Interaction Research Center, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0009-0009-1180-6222
So Jin KimDepartment of Molecular Physiology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Vessel-Organ Interaction Research Center, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0009-0007-5483-523X
Ye Seong JeonDepartment of Molecular Physiology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Vessel-Organ Interaction Research Center, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0009-0004-2076-0469
Kyung Min BaekDepartment of Cardiovascular and Neurologic Disease, College of Oriental Medicine, Daegu Haany University, Daegu, Korea.ORCID https://orcid.org/0000-0002-9898-7987
Woochul ChangDepartment of Biology Education, College of Education, Pusan National University, Busan, Korea.ORCID https://orcid.org/0000-0001-7367-2586
Kyung Seob LimFuturistic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Korea.ORCID https://orcid.org/0000-0002-9117-887X
Joong Sun KimDepartment of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.ORCID https://orcid.org/0000-0003-2180-4860
Seung Pil YunDepartment of Pharmacology, School of Medicine, Gyeongsang National University, Jinju, Korea.ORCID https://orcid.org/0000-0002-5151-8534
Min Young LeeDepartment of Molecular Physiology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Vessel-Organ Interaction Research Center, Kyungpook National University, Daegu, Korea.ORCID https://orcid.org/0000-0003-0067-2803

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various animal and cellular Alzheimer's disease (AD) models harboring familial AD (fAD) mutations have been developed and widely used for AD research. In this study, we established an AD cerebral organoid (CO) model using a novel Val669Leu (

Indexed as

Alzheimer’s diseaseDisease modelsDrug screeningHuman embryonic stem cellsOrganoid

Identifiers

PMID42521490
PMCPMC13519537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.