Evidence map›Paper›PMID 42521470›Full record

Trial reportJournal of clinical periodontology2026

Soft-Tissue Augmentation During Implant Placement in the Aesthetic Zone: Clinical, Radiographic, Histological and Patient-Reported Outcomes From a Randomised Controlled Trial Using Connective Tissue Graft and a Volume-Stable Collagen Matrix.

Louiza Papantonatou, Leonidas Batas, Antigoni Delantoni, Eleutherios Anagnostou, Ioannis Vouros

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06622759 (The Use of a Porcine Collagen Matrix for the Prevention of Buccal Bone Wall During Implant Placement in the Aesthetic Zone. A Randomized Controlled Clinical Trial.), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06622759 phase2recruitingnot on this map

The Use of a Porcine Collagen Matrix for the Prevention of Buccal Bone Wall During Implant Placement in the Aesthetic Zone. A Randomized Controlled Clinical Trial.

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2023 to 2025Enrolled36ConditionsSoft Tissue AugmentationArmsCTG, Collagen Matrix, Control group
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Louiza PapantonatouDepartment of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID https://orcid.org/0009-0003-4078-4305
Leonidas BatasDepartment of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID https://orcid.org/0000-0002-6381-2095
Antigoni DelantoniDepartment of Oral and Maxillofacial Surgery, Implant Surgery, and Radiology, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID https://orcid.org/0000-0002-5679-6779
Eleutherios AnagnostouSchool of Dentistry, Department of Stomatology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Ioannis VourosDepartment of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the clinical, radiographic, histological and patient-reported outcome measures (PROMs) of soft-tissue augmentation (STA) during implant placement in the aesthetic zone using a connective tissue graft (CTG) or a volume-stable collagen matrix (VCMX). MATERIALS AND

methodsIn this three-arm randomised controlled trial, 25 patients were allocated to VCMX, SCTG, or no augmentation (control). Soft-tissue thickness (STT) was assessed by ultrasonography, and buccal bone thickness (BBT) by CBCT, at baseline and 6 months. Clinical parameters, PROMs and histological findings were recorded. Statistical analysis was performed at the patient level using repeated-measures general linear models, accounting for within-subject variability.

resultsBoth VCMX and SCTG resulted in significant increases in STT compared with control (p < 0.001). Numerically greater STT gains were observed in the VCMX group. BBT decreased significantly over time in all groups, with no significant differences between treatments. PROMs were comparable, although CTG was associated with slightly higher morbidity. Histological analysis showed favourable integration of both grafting materials.

conclusionSTA significantly increased STT but did not prevent buccal bone remodelling. Within the study limitations, both augmentation approaches were associated with increased STT compared with no augmentation. Further well-designed studies are required to confirm these findings.

trial registrationThis study is registered at ClinicalTrials.gov (ClinicalTrials.gov Identifier: NCT06622759; URL: https://clinicaltrials.gov/study/NCT06622759).

Indexed as

CollagenConnective TissueDental Implantation, EndosseousDental ImplantsEsthetics, DentalGingivaGingivoplastyAdultAlveolar Ridge AugmentationCone-Beam Computed TomographyFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresTreatment OutcomeCollagenDental Implantsaesthetic zonecollagen matrixconnective tissue graftimplantssoft‐tissue augmentation

Identifiers

PMID42521470
PMCPMC13581467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.