ReviewModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2026
Follicular-Patterned Lesions of the Thyroid Gland.
Review in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Follicular-patterned thyroid lesions are common and are composed of a wide spectrum of thyroid lesions, including nonneoplastic, benign/low-risk neoplastic, to malignant lesions. The pathologic classifications of these lesions are based predominantly on 3 features: (1) the invasion status, (2) the nuclear features of papillary thyroid carcinoma (PTC), and (3) the presence of >75% oncocytic cells. This review summarizes the diagnostic criteria, subtyping, pathologic features, differential diagnosis, clinical characteristics, and molecular findings of follicular-patterned thyroid lesions, including follicular nodular disease, follicular adenoma, follicular carcinoma, oncocytic adenoma, oncocytic carcinoma, noninvasive follicular thyroid neoplasm with papillary-like nuclear features, thyroid tumor of uncertain malignant potential, PTC infiltrative follicular subtype, and invasive encapsulated follicular variant of PTC.
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