Evidence map›Paper›PMID 42520806›Full record

Trial reportCell reports. Medicine2026

Real-time AR navigation with dynamic tracking for millimeter-level pulmonary nodule localization: A randomized clinical trial.

Shenghao Huang, Long Wang, Xishi Wang, Weiyan Sun, Fei Sun, Zihan Guo, Mengmeng Zhao, Tao Chen, Jialiang Wen, Xinchen Shen and 9 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06335563 (Application of Intelligent Augmented Reality Glasses in Assisting the Localization of Small Pulmonary Nodules), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06335563 naunknown statusnot on this map

Application of Intelligent Augmented Reality Glasses in Assisting the Localization of Small Pulmonary Nodules:A Prospective, Randomized, Controlled, Noninferiority Trial

TypeinterventionalSponsorShanghai Pulmonary Hospital, Shanghai, ChinaRan2024 to 2024Enrolled166ConditionsPulmonary NoduleArmsAR glasses-assisted pulmonary nodule puncture localization, CT-guided pulmonary nodule puncture localization
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shenghao HuangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Long WangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Xishi WangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Weiyan SunDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Fei SunDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Zihan GuoDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Mengmeng ZhaoDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Tao ChenDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Jialiang WenDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Xinchen ShenDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Xinyu ShiDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Lei ZhangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Ziwei WanDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Qiankun ChenDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Jiajun DengDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Yunlang SheDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Dong XieDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: xiedong@tongji.edu.cn.
Deping ZhaoDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: zdp1992@163.com.
Chang ChenDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: changchenc@tongji.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise localization of small pulmonary nodules is crucial for surgery. Augmented reality (AR) navigation provides real-time guidance, potentially improving localization efficiency. This open-label randomized controlled trial compares AR-guided localization with conventional computed tomography (CT)-guided localization in 168 participants with peripheral pulmonary nodules ≤2 cm. The primary outcome is localization accuracy; secondary outcomes are success rate, procedural time, radiation dose, insertion attempts, and complications. In the intention-to-treat population, the AR group shows significantly lower localization error than the CT group (4.50 ± 3.07 vs. 6.50 ± 3.54 mm), with shorter procedural time, lower radiation exposure, and fewer needle adjustments. Both groups show high success rates and similar complication rates, with no severe adverse events. AR-guided localization provides noninferior accuracy while reducing radiation exposure and procedural time, supporting an efficient alternative to CT guidance. The trial is registered at www.clinicaltrials.gov (NCT06335563).

Indexed as

Augmented RealityLung NeoplasmsSolitary Pulmonary NoduleSurgery, Computer-AssistedAgedFemaleHumansMaleMiddle AgedTomography, X-Ray Computedaugmented realityCT-guided localizationpulmonary nodule localizationreal-time navigationthoracic surgery

Identifiers

PMID42520806
PMCPMC13522787

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.