ArticleCell genomics2026
Chromatin topology and distal elements underlie divergent cell-type-specific regulation of 9p21 locus cell cycle genes.
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Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
29 authors.
Elena Torlai TrigliaThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.
Tyler E MillerThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Neva C DurandThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Kyung Lock KimDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Salvador Casaní-GaldónThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Joshua D'AntonioThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Nauman JavedThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Alessandro Paz HernandezThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ayush RamanThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Anna J CruzThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Robbyn IssnerThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Abhishek ChoudharyThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
François AguetThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Julia VergaDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Michelle ChanCalico Life Sciences LLC, 1170 Veterans Blvd., South San Francisco, CA 94080, USA.
Varshini RamanathanThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.
Carman Man-Chung LiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Vivian HechtThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Anders S HansenThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.
Martin J AryeeDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Charles B EpsteinThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
David R KelleyCalico Life Sciences LLC, 1170 Veterans Blvd., South San Francisco, CA 94080, USA.
Fadi J NajmThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Noam ShoreshThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Kristin ArdlieThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
David G HendricksonCalico Life Sciences LLC, 1170 Veterans Blvd., South San Francisco, CA 94080, USA.
J Graham RubyCalico Life Sciences LLC, 1170 Veterans Blvd., South San Francisco, CA 94080, USA.
Bradley E BernsteinThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: bradley_bernstein@dfci.harvard.edu.
Elizabeth GaskellThe Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: egaskell@broadinstitute.org.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 9p21 locus encodes critical cell cycle regulators p16
Indexed as
ChromatinChromosomes, Human, Pair 9Genes, cdcAnimalsCellular SenescenceCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16Gene Expression RegulationHumansTumor Suppressor Protein p14ARFChromatinCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16Tumor Suppressor Protein p14ARFANRILCDKN2Acell cycleCRISPRagene regulationp14(ARF)p15(INK4B)p16(INK4A)senescencetranscription
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.