ArticleChemical senses2026
Bowman's glands act as facultative stem cells following olfactory epithelial lesion.
Article in Chemical senses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Resident stem cells support tissue maintenance in self-renewing adult tissue niches, including the olfactory epithelium, the peripheral organ for smell. In adult mammals, olfactory basal cells support neurogenesis and barrier epithelial maintenance, but whether additional stem cell compartments contribute to olfactory epithelial reconstitution remains unclear. Using lineage tracing, culture models, and single-cell RNA sequencing (scRNA-seq), we demonstrate directly that cells within adult murine submucosal Bowman's glands give rise to olfactory epithelial sustentacular cells, only after severe epithelial lesion. Modeling scRNA-seq data identifies BMP family ligands, expressed by basal stem cells, as potential signals modulating Bowman's gland differentiation. We developed a Bowman's gland culture model, providing an in vitro platform for testing differentiation. Informed by scRNA-seq modeling, treatment of cultures with BMP7/GDF5/GDF11 drove sustentacular cell differentiation. Together, these findings identify Bowman's glands as an injury-responsive facultative stem cell population capable of contributing to olfactory epithelial repair, a process necessary for maintenance of olfactory function.
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