Evidence map›Paper›PMID 42519715›Full record

ArticleNeurology. Genetics2026

The Association Between

Natalia Lakomski, Katherine Giorgio, John Stephen, Maxwell Mansolf, Aïcha Soumaré, Alden L Gross, Allison E Aiello, Archana Singh-Manoux, M Arfan Ikram, Catherine Helmer and 26 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neurology. Genetics · 2026
    Article
4 · The record

Corrections and comments

  • Commented on by
    2026
5 · Who and what money

Authors and funding

36 authors.

Natalia LakomskiSchool of Public Health, University of Minnesota, Minneapolis.ORCID https://orcid.org/0009-0008-8365-4021
Katherine GiorgioSchool of Public Health, University of Minnesota, Minneapolis.ORCID https://orcid.org/0000-0002-1815-4732
John StephenFeinberg School of Medicine, Northwestern University, Chicago, IL.ORCID https://orcid.org/0000-0001-7309-9193
Maxwell MansolfFeinberg School of Medicine, Northwestern University, Chicago, IL.ORCID https://orcid.org/0000-0001-6861-8657
Aïcha SoumaréINSERM-University of Bordeaux, France.ORCID https://orcid.org/0000-0002-0178-6506
Alden L GrossBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.ORCID https://orcid.org/0000-0002-4678-0562
Allison E AielloMailman School of Public Health, Columbia University, New York, NY.ORCID https://orcid.org/0000-0001-7029-2537
Archana Singh-ManouxUniversity College London, United Kingdom.ORCID https://orcid.org/0000-0002-1244-5037
M Arfan IkramErasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0003-0372-8585
Catherine HelmerINSERM-University of Bordeaux, France.ORCID https://orcid.org/0000-0002-5169-7421
Claudia L SatizabalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center San Antonio.ORCID https://orcid.org/0000-0002-1115-4430
Deborah A LevineUniversity of Michigan Medical School, Ann Arbor.ORCID https://orcid.org/0000-0002-6864-8001
Donald M Lloyd-JonesChobanian & Avedisian School of Medicine, Boston University, MA.
Emily M BriceñoUniversity of Michigan Medical School, Ann Arbor.ORCID https://orcid.org/0000-0002-9360-8917
Farzaneh A SorondFeinberg School of Medicine, Northwestern University, Chicago, IL.ORCID https://orcid.org/0000-0002-6127-0739
Frank J WoltersErasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0003-2226-4050
Jayandra J HimaliGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center San Antonio.ORCID https://orcid.org/0000-0003-1391-9481
Lenore J LaunerNational Institute on Aging, National Institutes of Health, Bethesda, MD.ORCID https://orcid.org/0000-0002-3238-7612
Djass MbangdadjiNational Institute on Aging, National Institutes of Health, Bethesda, MD.ORCID https://orcid.org/0009-0004-6841-467X
David LiNational Institute on Aging, National Institutes of Health, Bethesda, MD.ORCID https://orcid.org/0000-0003-2474-3485
Lihui ZhaoFeinberg School of Medicine, Northwestern University, Chicago, IL.ORCID https://orcid.org/0000-0002-6877-9490
Oscar L LopezDepartments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, PA.ORCID https://orcid.org/0000-0002-8546-8256
Stéphanie DebetteINSERM-University of Bordeaux, France.ORCID https://orcid.org/0000-0001-8675-7968
Sudha SeshadriGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center San Antonio.ORCID https://orcid.org/0000-0001-6135-2622
Suzanne E JuddSchool of Public Health, University of Alabama at Birmingham, AL.ORCID https://orcid.org/0000-0001-7594-6587
Timothy M HughesWake Forest School of Medicine, Winston-Salem, NC.ORCID https://orcid.org/0000-0002-2919-7199
Vilmundur GuðnasonFaculty of Medicine, University of Reykjavik, Iceland.ORCID https://orcid.org/0000-0001-5696-0084
Michael GriswoldUniversity of Mississippi Medical Center, Jackson.ORCID https://orcid.org/0000-0001-8106-5516
Paul S de VriesHuman Genetics Center, Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston; and.
Alison FohnerSchool of Public Health, University of Washington, Seattle.ORCID https://orcid.org/0000-0003-4231-3331
Pamela L LutseySchool of Public Health, University of Minnesota, Minneapolis.ORCID https://orcid.org/0000-0002-1572-1340
Rachel ZmoraFeinberg School of Medicine, Northwestern University, Chicago, IL.ORCID https://orcid.org/0000-0002-2553-2471
Elizabeth A PetersonFeinberg School of Medicine, Northwestern University, Chicago, IL.ORCID https://orcid.org/0009-0006-0090-2604
Denise ScholtensFeinberg School of Medicine, Northwestern University, Chicago, IL.ORCID https://orcid.org/0000-0002-8252-7863
Norrina B AllenFeinberg School of Medicine, Northwestern University, Chicago, IL.ORCID https://orcid.org/0000-0002-6993-4384
Sanaz SedaghatSchool of Public Health, University of Minnesota, Minneapolis.ORCID https://orcid.org/0000-0002-8296-1811

Funding

Infrastructure for mentored access to CHS data and specimensR01HL172803 · NHLBI · UNIVERSITY OF WASHINGTON · PI James S Floyd, Michelle Christina Odden · 2025 to 2026
$2.7M
NHLBI NIH HHS R01 HL172803
6 · The paper itself

Abstract

Background and Objectives: The apolipoprotein E ( Methods: Data from 7 large, community-based, prospective cohort studies from the Dementia Risk Prediction Pooling Project: Age, Gene/Environment Susceptibility-Reykjavik Study, Whitehall II study, Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, Honolulu-Asia Aging Study, Multi-Ethnic Study of Atherosclerosis, and Framingham Heart Study and its associated cohorts were used. Cox proportional hazard models were used to estimate the cause-specific hazard ratios of dementia by Results: The study consisted of 45,022 participants (10% Asian, 15% Black, 75% White, 52% male) with a mean age of 56 years (SD: 14.5) at baseline. Compared with participants with an Discussion: In this large, pooled cohort, the presence of at least one

Identifiers

PMID42519715
PMCPMC13382979

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.