Evidence map›Paper›PMID 42519705›Full record

ArticleFrontiers in microbiology2026

Gut microbiota signatures associated with lithium treatment and clinical response in patients with bipolar disorder.

Vanessa Palmas, Lívia Cavalcanti de Morais Gama, Suzana Eiko Sato Guima, Giuseppina Sanna, Claudia Pisanu, Cristina Piras, Martina Spada, Anna Meloni, Donatella Congiu, Giovanni Severino and 13 more

Abstract read
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In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Vanessa PalmasDepartment of Biomedical Sciences, Microbiology and Virology Unit, University of Cagliari, Monserrato, Italy.
Lívia Cavalcanti de Morais GamaDepartment of Biochemistry, Institute of Chemistry, University of São Paulo (USP), São Paulo, Brazil.
Suzana Eiko Sato GuimaDepartment of Biochemistry, Institute of Chemistry, University of São Paulo (USP), São Paulo, Brazil.
Giuseppina SannaDepartment of Biomedical Sciences, Microbiology and Virology Unit, University of Cagliari, Monserrato, Italy.
Claudia PisanuDepartment of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
Cristina PirasSection of Pathology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Martina SpadaSection of Pathology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Anna MeloniDepartment of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
Donatella CongiuDepartment of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
Giovanni SeverinoDepartment of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
Raffaella ArdauUnit of Clinical Pharmacology, University Hospital Agency of Cagliari, Cagliari, Italy.
Caterina ChillottiUnit of Clinical Pharmacology, University Hospital Agency of Cagliari, Cagliari, Italy.
Martina ContuSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Pasquale ParibelloSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Marco PinnaSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Federico SupraniUnit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy.
Maria Del ZompoDepartment of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
Bernardo CarpinielloSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Mirko ManchiaSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
João Carlos SetubalDepartment of Biochemistry, Institute of Chemistry, University of São Paulo (USP), São Paulo, Brazil.
Luigi AtzoriSection of Pathology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Alessio Squassina *Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
Aldo Manzin *Department of Biomedical Sciences, Microbiology and Virology Unit, University of Cagliari, Monserrato, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lithium, the gold-standard treatment for bipolar disorder, exhibits highly heterogeneous clinical responses and no validated biological predictors of responsiveness are currently available. Emerging evidence suggests that the gut microbiota influences mood disorders and psychotropic drug response, raising the hypothesis that specific microbial signatures may modulate lithium responsiveness. In this study, we characterized taxonomic and functional gut microbiota profiles in 77 patients with bipolar disorder, of whom 40 were receiving lithium (20 responders, 20 non-responders) and 37 were treated with valproate as the main mood stabilizer (valproate,

Indexed as

16S rRNAbipolar disordergut microbiotalithiummicrobiota gut–brain axisnext generation sequencingpatient-centered approach

Identifiers

PMID42519705
PMCPMC13384019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.