Evidence map›Paper›PMID 42519697›Full record

ArticleFrontiers in microbiology2026

Influence of commensal bacteria on the proteolytic and antigenic profiles of INFOGEST-like digested wheat gliadin.

Flávio Pereira-Costa, Vanessa S Domingues, Ana Roque, Zaida L Almeida, Pedro F Cruz, Rachel Cordeiro, Daniela Trindade, Carla Moura, Joana B Melo, Sónia G Pereira and 1 more

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In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Flávio Pereira-Costa *CiTechCare, Centre for Innovative Care and Health Technology, School of Health Sciences, Polytechnic Institute of Leiria, Leiria, Portugal.
Vanessa S Domingues *CiTechCare, Centre for Innovative Care and Health Technology, School of Health Sciences, Polytechnic Institute of Leiria, Leiria, Portugal.
Ana Roque *CiTechCare, Centre for Innovative Care and Health Technology, School of Health Sciences, Polytechnic Institute of Leiria, Leiria, Portugal.
Zaida L Almeida *Department of Chemistry, Coimbra Chemistry Centre (CQC), Institute of Molecular Sciences (IMS), University of Coimbra, Coimbra, Portugal.
Pedro F CruzDepartment of Chemistry, Coimbra Chemistry Centre (CQC), Institute of Molecular Sciences (IMS), University of Coimbra, Coimbra, Portugal.
Rachel CordeiroCDRsp, Centre for Rapid and Sustainable Product Development, Polytechnic of Leiria, Marinha Grande, Portugal.
Daniela TrindadeCDRsp, Centre for Rapid and Sustainable Product Development, Polytechnic of Leiria, Marinha Grande, Portugal.
Carla MouraCDRsp, Centre for Rapid and Sustainable Product Development, Polytechnic of Leiria, Marinha Grande, Portugal.
Joana B MeloCytogenetics and Genomics Laboratory and iCBR-CIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Sónia G PereiraCiTechCare, Centre for Innovative Care and Health Technology, School of Health Sciences, Polytechnic Institute of Leiria, Leiria, Portugal.
Daniela C VazDepartment of Chemistry, Coimbra Chemistry Centre (CQC), Institute of Molecular Sciences (IMS), University of Coimbra, Coimbra, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Celiac disease (CeD) is a chronic autoimmune enteropathy developed by genetically predisposed individuals when exposed to gluten. Gluten gliadins, along with gut microbiota, may influence CeD onset and progression through mechanisms that remain unclear. Methods: Gliadin-degrading bacterial isolates obtained from CeD patients, and their 1st-degree relatives' stool and blood were identified ( Results and discussion: In the absence of the bacterial isolates, gliadin is poorly digested and self-assembles within 1 day into intermediate and large protein oligomers/aggregates, enriched in β-sheet structure (FTIR amide I band between 1,600 and 1,700 cm

Indexed as

alpha-gliadinantigenic gliadin fragmentsanti-gliadin ELISAceliac diseasegliadin-degrading bacteriaINFOGEST in vitro digestionprotein aggregatesproteolytic cleavage

Identifiers

PMID42519697
PMCPMC13384009

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.