A chemo-free thermo-sensitive necroptosis-inducing perfusate to enable potent hyperthermic intraperitoneal immunotherapy.

Yujie Zhu, Lin Zhang, Shiqi Yang, Chunjie Wang, Xiangyu Zhang, Ning Li, Zhuang Liu, Liangzhu Feng

Abstract read

In one paragraph

Article in National science review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yujie ZhuInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Biomedical Basic Research Center (BBRC) of Jiangsu Province, Engineering Research Center of RNA Medicine and Cell Therapy Technology, Ministry of Education, Soochow University, Suzhou 215123, China.

Lin ZhangDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Shiqi YangInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Biomedical Basic Research Center (BBRC) of Jiangsu Province, Engineering Research Center of RNA Medicine and Cell Therapy Technology, Ministry of Education, Soochow University, Suzhou 215123, China.

Chunjie WangInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Biomedical Basic Research Center (BBRC) of Jiangsu Province, Engineering Research Center of RNA Medicine and Cell Therapy Technology, Ministry of Education, Soochow University, Suzhou 215123, China.

Xiangyu ZhangInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Biomedical Basic Research Center (BBRC) of Jiangsu Province, Engineering Research Center of RNA Medicine and Cell Therapy Technology, Ministry of Education, Soochow University, Suzhou 215123, China.

Ning LiDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 10021, China.

Zhuang LiuInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Biomedical Basic Research Center (BBRC) of Jiangsu Province, Engineering Research Center of RNA Medicine and Cell Therapy Technology, Ministry of Education, Soochow University, Suzhou 215123, China.ORCID https://orcid.org/0000-0002-1629-1039

Liangzhu FengInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Biomedical Basic Research Center (BBRC) of Jiangsu Province, Engineering Research Center of RNA Medicine and Cell Therapy Technology, Ministry of Education, Soochow University, Suzhou 215123, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperthermic intraperitoneal chemotherapy (HIPEC) is widely performed for treating peritoneal malignancies, yet its clinical application remains limited by insufficient efficacies and risks in chemotherapy-associated side effects. This study demonstrates that mild hyperthermia enhances cancer cell sensitivity to hydrogen peroxide (H

Indexed as

hyperthermic intraperitoneal immunotherapynecroptosisthermo-sensitive necroptosis-inducing perfusatethermosensitization

Identifiers

PMID42519667

DOI10.1093/nsr/nwag321

PMCPMC13382887

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.