Evidence map›Paper›PMID 42519630›Full record

ArticleArthroscopy techniques2026

Surgical Technique for Treating Focal Osteochondral Knee Lesions Using an Aragonite-Based Biphasic Scaffold.

Eric Wang, Alexandra M Cancio-Bello, Katelyn T Koschmeder, Bryn Berens, Anikar Chhabra

Abstract read
In one paragraph

Article in Arthroscopy techniques, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric WangMayo Clinic Alix School of Medicine Mayo Clinic Arizona Phoenix Arizona U.S.A.ORCID https://orcid.org/0000-0001-7940-753X
Alexandra M Cancio-BelloDepartment of Orthopedic Surgery Mayo Clinic Phoenix Arizona U.S.A.
Katelyn T KoschmederDepartment of Orthopedic Surgery Mayo Clinic Phoenix Arizona U.S.A.ORCID https://orcid.org/0000-0002-9134-3652
Bryn BerensDepartment of Orthopedic Surgery Mayo Clinic Phoenix Arizona U.S.A.
Anikar ChhabraDepartment of Orthopedic Surgery Mayo Clinic Phoenix Arizona U.S.A.ORCID https://orcid.org/0000-0002-4264-079X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteochondral lesions of the knee, particularly in patients with early osteoarthritic changes, remain a clinical challenge. The Agili-C implant (CartiHeal, Smith & Nephew), an aragonite-based osteochondral scaffold, offers a single-stage, off-the-shelf solution designed to regenerate both cartilage and subchondral bone. Unlike cell-based therapies, Agili-C eliminates the need for cell harvesting, culturing, or bioreactors, and avoids the morbidity associated with autografts and allografts. Recent multicenter randomized controlled trials have showed superior functional outcomes and pain reduction with Agili-C compared to microfracture and debridement, even in patients with early osteoarthritis (Kellgren-Lawrence grades 0-3). This Technical Note describes the surgical technique for Agili-C implantation and highlights key technical pearls to optimize outcomes.

Identifiers

PMID42519630
PMCPMC13383902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.