ArticleFrontiers in physiology2026
Physiological predictors of exercise-induced increases in circulating BDNF isoforms and net cerebral lactate exchange in healthy adults.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We previously showed an acute intensity-dependent increase in circulating brain-derived neurotrophic factor (BDNF) after aerobic exercise, without a concurrent increase in its release from the brain. Several exercise-related factors have been suggested to influence BDNF signalling and lactate dynamics, implicated in neuroplastic processes. We investigated whether pre-exercise levels and exercise-induced changes in platelet count, lactate, cortisol and noradrenaline predict changes in forearm venous serum mature BDNF (mBDNF-S) and its precursor proBDNF. As lactate may stimulate neuronal BDNF expression, net cerebral lactate exchange (LAC-AV-B) and its correlates, including mBDNF-S and proBDNF, were investigated. An association with the proportion of fast-twitch muscle fibre cross-sectional area (fCSA%-II) and the moderating effect of BDNF genotype were also examined. Healthy, physically fit adults (n=16, 31 ± 6 yrs) cycled for 20 min at 40, 60 and 80% of VO
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