ArticleFrontiers in allergy2026
Psychological burden in anaphylaxis: a study on alexithymia and quality of life.
Article in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: This study examines the impact of psychological burden on quality of life (QoL) in patients with anaphylaxis, assessing the relationship between alexithymia, QoL, and the presence of anxiety or depression. Materials and methods: A total of 29 patients with a confirmed diagnosis of anaphylaxis and a prescription for self-injectable epinephrine were recruited. Their QoL, psychological stress levels, and potential presence of anxiety, depression, and alexithymia were assessed using validated questionnaires: The Anaphylaxis Quality of Life Scale for Adults (A-QoL-Adults), the World Health Organization Quality of Life Scale - Brief Version (WHOQoL-BREF), the Perceived Stress Scale (PSS), the Hospital Anxiety and Depression Scale (HADS-A and HADS-D), and the Toronto Alexithymia Scale (TAS-20). Scores were compared, and statistical analyses were conducted. Results: Of the 29 patients who completed the questionnaires, 11 (37.9%) were classified as alexithymic or borderline alexithymic. A moderate positive correlation was observed between TAS-20 scores and perceived anaphylaxis severity (r = 0.435, Conclusion: This study underscores the significant correlation between alexithymia and QoL in patients with anaphylaxis. Integrating psychological assessments into anaphylaxis management may enable healthcare providers to develop more comprehensive strategies beyond physical symptom control. A holistic approach-including education, emotional support, and psychological interventions-could enhance long-term outcomes for patients prescribed epinephrine auto-injectors.
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