ArticleJournal of blood medicine2026
Estimated Whole Blood Viscosity in Smoldering Multiple Myeloma: Preliminary Data from a Retrospective Single Center Analysis.
Article in Journal of blood medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: In recent years, several reports have been available about the hemorheological profile in plasma cell dyscrasias, but a specific mention of smoldering multiple myeloma is present in few papers. Therefore, we decideded to evaluate the calculated whole blood viscosity and some important related laboratory parameters in this clinical condition. Patients and methods: We performed a specific analysis aimed to evaluate the calculated blood viscosity using the de Simone formula, and some laboratory parameters and erythrocyte indices, in a cohort of 80 patients with smoldering multiple myeloma (median age 68.50; 40 male and 40 female, median follow-up of 26 months). Results: From our analysis it emerges that in IgA smoldering multiple myeloma there is a greater bone marrow plasma cell infiltration and a reduction of albumin levels. Furthermore, in relation to the risk of progression into multiple myeloma we observed, in the non-low risk subgroup, a significant increase in total proteinemia, without any variation in blood viscosity. The latter is in fact almost exclusively dependent on hematocrit values, and it is negatively correlated to the ratio of free light chains. Conclusion: In our group of smoldering multiple myeloma patients the calculated whole blood viscosity does not appear to change with the risk of disease progression, and it seems to depend almost exclusively on hematocrit value. Furthermore, we observed a negative correlation between blood viscosity and rFLC in which it might depend on the fact that the latter parameter is negatively correlated with the hematocrit values, that significantly affect blood viscosity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.