ArticleData in brief2026
Comprehensive characterization of myopic guinea pigs' retina following PI3K/AKT inhibition using a data-independent acquisition dataset on an Orbitrap Exploris 480 mass spectrometer.
Article in Data in brief, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Myopia has emerged as a global ocular health concern. The progression of myopia is predominantly driven by abnormal signaling pathways, with the PI3K/AKT pathway playing a crucial role. By utilizing the lens-induced myopia model in guinea pigs, we intravitreally injected the PI3K/AKT inhibitor LY294002 and carried out quantitative proteomic analysis using data-independent acquisition mass spectrometry. In this research, proteomic data of the retinas from guinea pigs in the normal, myopic, and drug-treated groups were provided. Moreover, a comprehensive retinal proteome database for guinea pig myopia was established, providing a resource for future investigations into myopia-related signaling pathways. All mass spectrometry data were deposited in the ProteomeXchange Consortium via the PRIDE partner (https://www.ebi.ac.uk/pride) with the dataset identifier PRIDE: PXD074201.
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