Evidence map›Paper›PMID 42519478›Full record

ArticleCell insight2026

GPAT4 regulates antitumor immune response through activating the mtDNA-cGAS axis in cancer cells.

Zi-Lun Ruan, Wei Liang, Yu-Tong Gong, Wei-Tao Guan, Xuan-Ang Zhou, Kai Jiang, Qing Yang, Ming-Ming Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zi-Lun RuanDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, State Key Laboratory of Virology and Biosafety, Wuhan University, Wuhan, 430071, Hubei, China.
Wei LiangDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, State Key Laboratory of Virology and Biosafety, Wuhan University, Wuhan, 430071, Hubei, China.
Yu-Tong GongDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, State Key Laboratory of Virology and Biosafety, Wuhan University, Wuhan, 430071, Hubei, China.
Wei-Tao GuanThe First Clinical College of Wuhan University, Wuhan, 430071, Hubei, China.
Xuan-Ang ZhouCollege of Life Sciences of Wuhan University, Wuhan, 430071, Hubei, China.
Kai JiangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Medical Research Institute, Wuhan University, Wuhan, 430071, Hubei, China.
Qing YangDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, State Key Laboratory of Virology and Biosafety, Wuhan University, Wuhan, 430071, Hubei, China.
Ming-Ming HuDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, State Key Laboratory of Virology and Biosafety, Wuhan University, Wuhan, 430071, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activating tumor-intrinsic innate immune pathways can promote tumor antigen presentation and immune cell recruitment, thereby improving the immunosuppressive microenvironment and overcoming resistance to immune checkpoint blockade (ICB). However, the specific molecular targets remain insufficiently defined. Bioinformatic analysis revealed that Glycerol-3-phosphate acyltransferase 4 (GPAT4) is highly expressed in various tumors, including pancreatic cancer and breast cancer, and is significantly associated with low immunogenicity, poor immune-cell infiltration, and unfavorable prognosis. Syngeneic C57BL/6J and BALB/c tumor-bearing experiments showed that

Indexed as

Antitumor immunityBioinformaticscGAS-mediated innate immunityGPAT4Mitochondrial DNA

Identifiers

PMID42519478
PMCPMC13382030

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.