Evidence map›Paper›PMID 42519410›Full record

ArticleJTO clinical and research reports2026

Concurrent Hypertrophic Osteoarthropathy and Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis in a Patient With NSCLC: A Case Report.

Isaac K S Ng, Kaung Myat, Salil B Singbal, Victor G H Lee, Manjari Lahiri, Sen Hee Tay, May Shuen Tang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JTO clinical and research reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Isaac K S NgDivision of Rheumatology and Allergy, Department of Medicine, National University Hospital, Singapore.
Kaung MyatDepartment of Diagnostic Imaging, National University Hospital, Singapore.
Salil B SingbalDepartment of Diagnostic Imaging, National University Hospital, Singapore.
Victor G H LeeDepartment of Hematology-Oncology, National University Cancer Institute, Singapore.
Manjari LahiriDivision of Rheumatology and Allergy, Department of Medicine, National University Hospital, Singapore.
Sen Hee TayDivision of Rheumatology and Allergy, Department of Medicine, National University Hospital, Singapore.
May Shuen TangDivision of Rheumatology and Allergy, Department of Medicine, National University Hospital, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertrophic osteoarthropathy (HOA) is a prototypical paraneoplastic arthritis associated with lung cancer, specifically NSCLC. With the increasing use of immune checkpoint inhibitors (ICIs), ICI-induced inflammatory arthritis (IA) is another important differential diagnosis for joint pain in patients with lung cancer. We report, to our knowledge, the first case of a patient with stage 4 lung adenocarcinoma and paraneoplastic HOA who subsequently developed ICI-IA and cytokine release syndrome while receiving the PD-1 inhibitor, pembrolizumab. Differentiating between HOA and ICI-IA is essential because of their differing treatment implications, requiring careful clinical assessment with adjunctive biochemical (including cytokine profiling), radiological, and synovial fluid investigations.

Indexed as

Case reportCytokine release syndromeHypertrophic osteoarthropathyImmune checkpoint inhibitorInflammatory arthritis

Identifiers

PMID42519410
PMCPMC13382932

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.