ArticleJPRAS open2026
Complication rate after implant-based breast-reconstruction with support of a synthetic non-resorbable titanized polypropylene mesh (TiLOOP® Bra): Analysis of the 2-year follow up from the prospective multicentre PRO-BRA trial.
Article in JPRAS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01885572 (National, Multicenter Post-market Surveillance Study "Patient Reported Outcome" in Breast Reconstruction Following Mastectomy With Titaniferously Coated Polypropylene Mesh), which is not on this map. Not yet cited in PubMed.
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National, Multicenter Post-market Surveillance Study "Patient Reported Outcome" in Breast Reconstruction Following Mastectomy With Titaniferously Coated Polypropylene Mesh (TiLOOP Bra)
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Specific patient characteristics and certain cancer treatments increase the risk for postoperative complications in implant-based breast reconstructions. It is therefore essential to identify those risk factors and analyse their contribution to the outcome. Methods: Implant-based breast reconstruction with support of synthetic non-resorbable titanized polypropylene surgical mesh (TiLOOP® Bra) was performed in 269 patients during the prospective, multicentre PRO-BRA cohort trial (clinicaltrials.gov: NCT01885572, DRKS: DRKS00005342). Secondary endpoint was the evaluation of the postoperative complication rate 24 months after breast reconstruction. Univariable and multivariable logistic regression analyses were performed to identify specific factors (e.g. BMI, age, radiotherapy, chemotherapy, implant size) increasing the risk for complications. Results: In 362 breast reconstructions the following factors were identified in univariable logistic regression to be associated with an increased risk for distinct complications: Implant volume, BMI (complication irrespective of type, seroma, wound complications), adjuvant radiotherapy (capsular fibrosis), Charlson Comorbidity Index (first complication, seroma), age (seroma), transverse/vertical incision (wound complications), and adjuvant chemotherapy (infection/inflammation). Multivariable logistic regression identified neoadjuvant chemotherapy as significant risk factor for the occurrence of complications. Conclusion: The following factors have been identified as increasing the risk of developing postoperative complications of implant-based breast reconstruction with a non-resorbable titanized polypropylene surgical mesh (TiLOOP® Bra): larger implants, age of 50 years or over, BMI of 25 kg/m
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