Evidence map›Paper›PMID 42519393›Full record

ArticleMolecular therapy. Oncology2026

Oncolytic virus-mediated remodeling of tumor microenvironment enhances efficacy of an HPV16 E6/E7 mRNA vaccine in an HPV-positive tumor.

Kyle Johnson, Wanfu Wu, Jane JingTing Lim, Nguyet Tu, Shaun Xiaoliu Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyle JohnsonDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Wanfu WuDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Jane JingTing LimDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Nguyet TuDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Shaun Xiaoliu ZhangDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Funding

Actively engaging NK cells during virotherapy to induce neoantigen-specific antitumor immunityR01CA269002 · NCI · UNIVERSITY OF HOUSTON · PI SHAUN XIAOLIU ZHANG · 2022 to 2026
$1.9M
NCI NIH HHS R01 CA269002
6 · The paper itself

Abstract

Therapeutic vaccination targeting the viral oncoproteins E6 and E7 in HPV-positive tumors remains an attractive strategy; however, current HPV E6/E7 vaccines produced only limited clinical benefit. We developed mRNA-ubiquitin (UB)-E6/E7, an mRNA-based HPV16 E6/E7 construct incorporating an N-terminal UB tag to enhance antigen processing. UB tagging in the mRNA format significantly enhanced antigen-specific immune responses, leading to increased cytotoxic T lymphocyte (CTL) activity and higher frequencies of E7-specific CD8

Indexed as

antitumor immunitycervical cancerDNA vaccineherpes simplex virusHPV16 E6/E7lipid nanoparticlemRNA vaccineoncolytic virustumor vaccinevirotherapy

Identifiers

PMID42519393
PMCPMC13382575

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.