Evidence map›Paper›PMID 42519367›Full record

ArticleHemaSphere2026

Combined inhibition of de novo pyrimidine synthesis and ATR promotes ATF4-mediated cell death in

Kari J T Grünewald, Marjolein M G Kes, Gawin R Stoll, Willem P J Cox, Dorette S van Ingen Schenau, Enzo M Scutigliani, Emmely M Wagener, Ziqin Tang, Senna Visser, Jolanda Kooiman and 9 more

Abstract read
In one paragraph

Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kari J T GrünewaldPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0009-0009-5246-1734
Marjolein M G KesPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0009-0006-9564-5363
Gawin R StollPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0009-0005-4005-7460
Willem P J CoxPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0009-0004-7943-1459
Dorette S van Ingen SchenauPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.
Enzo M ScutiglianiPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0000-0003-2504-2058
Emmely M WagenerPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0009-0001-1607-128X
Ziqin TangPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0009-0009-3432-4779
Senna VisserPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0009-0005-6498-8462
Jolanda KooimanPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.
Jessica Buijs-GladdinesPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0009-0003-6098-4400
Maria RodionovaPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.
Esther A ZaalDivision Cell Biology, Metabolism & Cancer, Department Biomolecular Health Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands.ORCID https://orcid.org/0000-0001-9890-7345
Jeroen W A JansenDivision Cell Biology, Metabolism & Cancer, Department Biomolecular Health Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands.ORCID https://orcid.org/0009-0004-0023-4699
Jeroen F van VelzenPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.
Jarno DrostPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0000-0002-2941-6179
Laurens T van der MeerPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0000-0002-8996-2091
Celia R BerkersDivision Cell Biology, Metabolism & Cancer, Department Biomolecular Health Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands.ORCID https://orcid.org/0000-0003-0746-8565
Frank N van LeeuwenPrincess Máxima Center for Pediatric Oncology Utrecht The Netherlands.ORCID https://orcid.org/0000-0003-1107-6513

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations or deletions affecting the

Identifiers

PMID42519367
PMCPMC13384356

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.