ArticleInternational journal of general medicine2026
Metabolic Dysfunction Outweighs Inflammatory Burden in Association with Hyperuricemia: A Cross-Sectional Study in a Large Health Examination Cohort.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hyperuricemia is a common metabolic abnormality frequently identified during routine health examinations, but the relative contributions of metabolic dysfunction and systemic inflammation remain incompletely understood. Methods: In this cross-sectional study, data from individuals undergoing routine health examinations were analyzed. Inflammatory burden was assessed using the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR), and metabolic dysfunction was assessed using the triglyceride-glucose (TyG) index. Associations with hyperuricemia were evaluated using multivariable logistic regression, restricted cubic spline analyses, joint effect models, interaction testing, and subgroup analyses by sex and age. Results: Among 7959 participants included in the NHR analysis, 1398 (17.6%) had hyperuricemia. A metabolic subcohort of 4193 participants with complete triglyceride, fasting glucose, and covariate data was included in TyG-related analyses, among whom 781 (18.6%) had hyperuricemia. Each 1-SD increase in NHR was associated with hyperuricemia after multivariable adjustment (OR 1.16, 95% CI 1.09-1.25), whereas neutrophil percentage alone was not independently associated (OR 0.97, 95% CI 0.91-1.04). The TyG index showed a stronger association with hyperuricemia (OR 1.60, 95% CI 1.46-1.77). In models including both indices, the association between NHR and hyperuricemia was attenuated (OR 1.00, 95% CI 0.91-1.10), whereas TyG remained robust. Joint analyses showed that the high NHR/high TyG group had the highest risk of hyperuricemia (OR 2.61, 95% CI 2.01-3.39). Associations were generally consistent across sex and age strata. Conclusion: Metabolic dysfunction appears to have a stronger association with hyperuricemia than inflammatory burden in routine health examination populations. The apparent association between inflammatory burden and hyperuricemia may depend largely on underlying metabolic abnormalities. However, the cross-sectional design precludes causal inference.
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