Evidence map›Paper›PMID 42519351›Full record

ReviewJournal of pharmaceutical analysis2026

Therapeutic repurposing of old drugs to modulate the tumor immune microenvironment and enhance immunotherapy efficacy.

Yakai Song, Nannan Zheng, Xu Yang, Zhaofan Tao, Qinghui Wang, Zhiyue Cao, Yi Zhang, Mengmeng Li, Ruixin Mao, Yuhao Chen and 7 more

Abstract readReview
In one paragraph

Review in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yakai SongSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Nannan ZhengSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Xu YangSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Zhaofan TaoSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Qinghui WangSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Zhiyue CaoSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Yi ZhangSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Mengmeng LiSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Ruixin MaoSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Yuhao ChenSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Chen ZhaoSchool of Information Engineering, East University of Heilongjiang, Harbin, 150001, China.
Huanjie YangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Bin YangSchool of Instrumentation Science and Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Qiuyue MaSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Liangcan HeSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Shaoqin LiuSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.
Kai LiSchool of Medicine and Health, Harbin Institute of Technology, Harbin, 150001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although immunotherapy has demonstrated remarkable progress in cancer treatment, its clinical benefits remain restricted to a subset of patients and specific cancer types, primarily due to the immunosuppressive nature of the tumor microenvironment (TME) in solid tumors. Therefore, many strategies have focused on targeting the immunosuppressive TME to enhance immune-mediated tumor eradication. In parallel, the repositioning of old drugs represents an attractive discovery approach compared with the traditional

Indexed as

AntitumorDrug repositioningImmunosuppressionImmunotherapyTumor microenvironment

Identifiers

PMID42519351
PMCPMC13382183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.