ReviewFrontiers in immunology2026
Lambda restricted light chain as pathogenic cause of POEMS syndrome: a review of the hypothesis.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
POEMS syndrome is a rare and chronic paraneoplastic syndrome characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes. The pathophysiology of this disease is not well understood, but current research focuses on the increase in VEGF and the highly restrictive nature of λ light chains produced by monoclonal plasma cells. Recently, studies have looked deeper into the possibility of these λ light chains being a major factor in onset and progression of this disease focusing on molecular mimicry and links to viral infections. This mini review will summarize current literature on POEMS syndrome as well as hypothesize and analyze the role of the λ light chain in the pathophysiology of the disease.
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