Evidence map›Paper›PMID 42519337›Full record

ArticleFrontiers in immunology2026

Neonatal and pediatric thymic grafts generate similar human T-cell chimerism in humanized mice.

Natalia M Del Rio, Liupei Huang, Alexis M Holm, Wesley Blashka, Nicholas A Smith, Sayandeep Saha, Adam J Bell, Janell Richardson, Katherine E Badior, Christian J Kastrup and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Natalia M Del RioDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.
Liupei HuangDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.
Alexis M HolmDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.
Wesley BlashkaMedical College of Wisconsin, Milwaukee, WI, United States.
Nicholas A SmithTaconic Biosciences, Inc., Rensselaer, NY, United States.
Sayandeep SahaDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.
Adam J BellTaconic Biosciences, Inc., Rensselaer, NY, United States.
Janell RichardsonTaconic Biosciences, Inc., Rensselaer, NY, United States.
Katherine E BadiorVersiti Blood Research Institute, Milwaukee, WI, United States.
Christian J KastrupVersiti Blood Research Institute, Milwaukee, WI, United States.
Matthew E BrownDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.

Funding

Characterizing Emerging Humanized Immune Mouse Models for the study of transplant rejection and infectious disease pathology (Epstein Barr Virus)75N93021C00004 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BROWN, MATTHEW E · 2021 to 2023
$2.5M
NIAID NIH HHS 75N93021C00004
6 · The paper itself

Abstract

Human immune system (HIS) humanized mice, particularly those incorporating human thymic tissue and hematopoietic stem/progenitor cell (HSPC) co-transplantation, provide a powerful

Indexed as

Thymus GlandT-LymphocytesTransplantation ChimeraAnimalsAnimals, NewbornChimerismHematopoietic Stem Cell TransplantationHumansInfant, NewbornMiceBLT mousehumanized mousemRNA vaccineNeoThy mousethymopoiesisthymus transplantation

Identifiers

PMID42519337
PMCPMC13381199

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.