Evidence map›Paper›PMID 42519332›Full record

ArticleFrontiers in immunology2026

Donor-recipient HLA molecular mismatch and T follicular helper-related genetic variants are associated with dnDSA development after kidney transplantation.

Hidetoshi Shidahara, Kentaro Ide, Aiko Yamaoka, Yuki Imaoka, Seiichi Shimizu, Hiroyuki Tahara, Masahiro Ohira, Yuka Tanaka, Hideki Ohdan

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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hidetoshi ShidaharaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kentaro IdeDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Aiko YamaokaSection of Clinical Laboratory, Department of Clinical Support, Hiroshima University Hospital, Hiroshima, Japan.
Yuki ImaokaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Seiichi ShimizuDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Hiroyuki TaharaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Masahiro OhiraDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yuka TanakaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: In this retrospective single-center cohort study, we analyzed 210 kidney transplant recipients who underwent transplantation between 2011 and 2024. Donor-recipient HLA molecular mismatch loads were quantified using eplet mismatch analysis, Predicted Indirectly ReCognizable HLA Epitopes-T cell (PIRCHE-T2), and HLA Epitope Mismatch Algorithm (HLA-EMMA). Recipient single-nucleotide polymorphisms in Tfh-related genes ( Results: During follow-up, 20 recipients (9.5%) developed class II dnDSAs. Higher class II molecular mismatch loads were significantly associated with dnDSA development, with HLA-EMMA showing the strongest association among the evaluated metrics. In multivariable analysis, high HLA-EMMA class II load and Tfh cell-related immunogenetic variation were independently associated with class II dnDSA development. Recipients with both high HLA-EMMA class II load and Tfh-related polymorphisms showed the highest cumulative incidence of dnDSA development. Conclusion: These findings suggest that donor-derived structural antigenicity and recipient Tfh-related immunogenetic variation are associated with the development of class II dnDSAs after kidney transplantation. The identified thresholds and integrated risk stratification approach are exploratory and require validation in independent cohorts before clinical application of the model.

Indexed as

Graft RejectionHLA AntigensIsoantibodiesKidney TransplantationT Follicular Helper CellsT-Lymphocytes, Helper-InducerAdultFemaleHistocompatibility TestingHumansMaleMiddle AgedPolymorphism, Single NucleotideRetrospective StudiesTissue DonorsHLA AntigensIsoantibodiesalloimmunityde novo donor-specific antibodygerminal centerHLA molecular mismatchimmunogeneticskidney transplantationT follicular helper cell

Identifiers

PMID42519332
PMCPMC13381205

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.