Evidence map›Paper›PMID 42519321›Full record

ArticleFrontiers in immunology2026

RNF213 marks a regulatory T-cell subset associated with ulcerative colitis.

Zhangqin Li, Jing Wu, Jiayi Yang, Lianyu Zhou, Lifang Chen, Youxu Ren, Yunxing Li, Ruijie Ma, Yinglei Miao, Jie Jia and 1 more

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhangqin Li *Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Jing Wu *Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Jiayi Yang *Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Lianyu ZhouDepartment of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Lifang ChenDepartment of Gastroenterology, The People's Hospital of Xishuangbanna Dai Nationality Autonomous Prefecture, Xishuangbanna, China.
Youxu RenDepartment of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yunxing LiDepartment of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Ruijie MaDepartment of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yinglei MiaoDepartment of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Jie JiaResearch Center for Clinical Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Jiarong MiaoDepartment of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ulcerative colitis (UC) is a nonspecific autoimmune disease, the etiology and pathogenesis of which remain unclear. Identifying new disease targets could inform clinical diagnosis and treatment. Methods: We integrated single-cell RNA sequencing (scRNA-seq) and bulk transcriptome data from UC patients. We screened key biomarkers and constructed a nomogram diagnostic model through three machine learning algorithms (LASSO, SVM-RFE, and Boruta). Results: Five UC-specific ubiquitination biomarkers were identified: ZC3H12A, ENC1, RNF213, MAP3K5, and RMND5A. Among them, RNF213 demonstrated superior diagnostic performance with an AUC greater than 0.9 in both training and validation cohorts. Single-cell localization and Conclusions: This study identifies RNF213 as a biomarker enriched in UC-associated mucosal Tregs.

Indexed as

Colitis, UlcerativeT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsUbiquitin-Protein LigasesBiomarkersFemaleHumansIntestinal MucosaMaleSeven in Absentia ProteinsUbiquitinationBiomarkersSeven in Absentia ProteinsUbiquitin-Protein Ligasesinflammationregulatory T cellsRNF213ubiquitinationulcerative colitis

Identifiers

PMID42519321
PMCPMC13381293

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.