ArticleERJ open research2026
Peri-transplant frailty changes impact survival in interstitial lung diseases.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Post-transplant trajectories of the CRP-to-albumin ratio identify a late-emerging high-risk phenotype in interstitial lung disease.BMC pulmonary medicine · 2026Observational
- Deconditioning or biology? Triaging frailty in lung transplant candidates.ERJ open research · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Frailty is a dynamic state of vulnerability resulting from progressive functional decline and multimorbidity in patients with interstitial lung disease (ILD). The effect of lung transplantation (LTx) on frailty and its prognostic significance remains insufficiently understood. Methods: This single-centre cohort study aimed to characterise peri-transplant frailty trajectories, measured by the clinical frailty scale (CFS), and determine their impact on long-term survival in patients with ILD undergoing LTx. CFS was assessed pre-operatively, at 4-months and 5-years post-transplant. Patients were categorised as fit (CFS 1-3), vulnerable (CFS 4) or frail (CFS 5-9). Frailty change (ΔCFS) was classified as improved (ΔCFS ≤-1), unchanged (ΔCFS 0) or worsened (ΔCFS ≥+1). Survival was analysed using Kaplan-Meier estimates and Cox proportional hazards models. Results: The proportion of fit patients increased from 22.2% before to 87.5% 4 months and 75.0% 5 years post-transplant. Frailty improved in 93.1%, remained unchanged in 2.8% and worsened in 4.1% of patients. Median ΔCFS was -3 in frail, -1 in vulnerable and 0 in pre-LTx fit patients. Prolonged intensive care unit/hospital stay/ventilation was associated with reduced CFS recovery. Each one-point increase in ΔCFS was associated with a 1.76-fold higher mortality hazard (95% CI 1.34-2.31, p<0.001). Compared to those with improvement, patients with worsened frailty had a 43.9-fold higher mortality hazard (95% CI 10.1-173.2, p<0.001). Conclusions: Peri-transplant CFS trajectory is associated with long-term survival in ILD, underscoring frailty as a modifiable risk factor and highlighting the need for systematic assessment and targeted interventions to optimise outcomes throughout the transplant course.
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Registered trials
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