ArticleIDCases2026
Polymicrobial bloodstream infection caused by three carbapenemase-producing Enterobacterales species in a neutropenic cancer patient: Clinical and genomic characterization.
Article in IDCases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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15 authors.
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Abstract
Carbapenemase-producing Enterobacterales (CPE) represent a major global health threat due to limited therapeutic options and high mortality. While isolates harboring a single carbapenemase are increasingly common, polymicrobial bloodstream infections involving multiple carbapenemase-producing species remain rare and pose substantial diagnostic and therapeutic challenges. We describe a case of polymicrobial bloodstream infection in a neutropenic patient with relapsed acute myeloid leukemia. Blood cultures yielded three distinct Enterobacterales species. Identification was performed by MALDI-TOF MS, antimicrobial susceptibility testing followed CLSI guidelines, and carbapenemase production was screened by immunochromatographic assay and PCR. Whole-genome sequencing was conducted for all isolates, with in silico multilocus sequence typing, resistome characterization, plasmid replicon analysis, and phylogenetic reconstruction. A literature review (2015-2025) was performed to contextualize this finding. Three carbapenem-resistant Enterobacterales were simultaneously isolated from blood cultures:
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