Evidence map›Paper›PMID 42519122›Full record

ArticleCurrent developments in nutrition2026

Resistant Starch Supplementation Modulates Gut Microbiota, Short-Chain Fatty Acids, and Markers of Gut Barrier Integrity in Estrogen-Deficient Mice.

Femi Olawale, Sanmi E Alake, Ranjitha Chandrashekar, Proapa Islam, Brooke Sutton, Yabsira Argeta, Stanley Lightfoot, Winyoo Chowanadisai, Trina A Knotts, Brenda J Smith and 1 more

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Article in Current developments in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Femi OlawaleNutritional Sciences Department, Oklahoma State University, Stillwater, OK, United States.
Sanmi E AlakeNutritional Sciences Department, Oklahoma State University, Stillwater, OK, United States.
Ranjitha ChandrashekarNutritional Sciences Department, Oklahoma State University, Stillwater, OK, United States.
Proapa IslamNutritional Sciences Department, Oklahoma State University, Stillwater, OK, United States.
Brooke SuttonNutritional Sciences Department, Oklahoma State University, Stillwater, OK, United States.
Yabsira ArgetaNutritional Sciences Department, Oklahoma State University, Stillwater, OK, United States.
Stanley LightfootOklahoma City Veterans Affair, Department of Veterans Affairs, Oklahoma City, OK, United States.
Winyoo ChowanadisaiNutritional Sciences Department, Oklahoma State University, Stillwater, OK, United States.
Trina A KnottsCenter for Alimentary and Metabolic Science, Department of Surgery, University of California Davis School of Medicine, Sacramento, CA, United States.
Brenda J SmithDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indiana University, Indianapolis, IN, United States.
Edralin A LucasNutritional Sciences Department, Oklahoma State University, Stillwater, OK, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Menopause-associated estrogen decline promotes gut dysbiosis and impaired gut health, but the effects of resistant starch (RS) under estrogen-deficient conditions remain unclear. Objectives: Herein, we examine the effects of retrograded (RS3) and chemically modified (RS4) RS on the gut microbiota and gut barrier integrity in estrogen-deficient mice. Methods: In this study, 3-mo-old female C57BL/6 mice received the ovotoxicant vinyl cyclohexene diepoxide (VCD, 160 mg/kg) or sesame oil (vehicle) for 30 d, followed by 16 wk of dietary intervention with control (AIN-93M), 5% RS3, or 5% RS4 ( Results: RS supplementation induced distinct clustering in bacterial Conclusions: These findings suggest that RS supplementation modulates gut microbiota composition, SCFA production, and inflammatory markers, with RS4 showing stronger anti-inflammatory effects and RS3 preferentially enhancing antimicrobial peptide expression, in estrogen-deficient mice.

Indexed as

estrobolomeestrogen deficiencygut dysbiosismenopauseprebioticsresistant starch

Identifiers

PMID42519122
PMCPMC13382294

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.