ReviewRSC advances2026
From weak adsorption to selective detection: functionalized interfaces for SERS glucose sensing.
Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Surface-enhanced Raman scattering (SERS) offers molecularly specific, highly sensitive, and potentially miniaturized analysis for glucose sensing, but glucose remains an intrinsically difficult SERS target on bare noble-metal surfaces. As a neutral, highly hydrated, weakly adsorbing aliphatic polyol, glucose does not readily populate plasmonic hotspots or form a stable, selective, and spectroscopically productive interfacial state. Consequently, the central limitation in SERS glucose sensing is not simply weak Raman scattering, but the mismatch between glucose chemistry and the interfacial requirements of SERS detection. This review examines functionalized interfaces as the main route for overcoming that mismatch. We first discuss the SERS principles most relevant to glucose sensing, including electromagnetic and chemical enhancement, distance dependence, adsorption probability, molecular orientation, and matrix competition. We then analyze boronic-acid-centered interfaces, which currently represent the most developed practical strategy because they combine reversible
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