Evidence map›Paper›PMID 42519064›Full record

ArticleiScience2026

The genomic sequence of packaged viral ribonucleic acid predicts mucosal HIV-1 transmission fitness.

Rahul Pawa, Iulian Derecichei, Katja Klein, Muhammad Ali, Chanuka N Wijewardhana, Richard Gibson, Ryan M Troyer, Robin J Shattock, Eric J Arts, Jamie F S Mann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rahul PawaDepartment of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5C1, Canada.
Iulian DerecicheiDepartment of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5C1, Canada.
Katja KleinDepartment of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5C1, Canada.
Muhammad AliDepartment of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5C1, Canada.
Chanuka N WijewardhanaDepartment of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5C1, Canada.
Richard GibsonDepartment of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5C1, Canada.
Ryan M TroyerDepartment of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5C1, Canada.
Robin J ShattockDepartment of Infectious Diseases, Division of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK.
Eric J ArtsDepartment of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5C1, Canada.
Jamie F S MannDepartment of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5C1, Canada.

Funding

Impact of HIV-1 Fitness on Disease ProgressionR01AI049170 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI ARTS, ERIC J · 2002 to 2024
$6.8M
HIV-1 Fitness and RecombinationR56AI049170 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ARTS, ERIC J · 2012 to 2012
$400k
Impact of HIV-1 Fitness on Disease ProgressionR21AI049170 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ARTS, ERIC J · 2001 to 2001
$265k
NIAID NIH HHS R01 AI049170NIAID NIH HHS R21 AI049170NIAID NIH HHS R56 AI049170
6 · The paper itself

Abstract

RNA viruses are responsible for many zoonotic disease transmission events, and remain a global health challenge. To evade immune detection, RNA viruses suppress the numbers of immunostimulatory oligonucleotide motifs (INMs) present in their genomes. Although this is thought to occur in human immunodeficiency virus-1 (HIV-1), our bioinformatic analysis on well characterized clinical datasets, along with

Indexed as

HIVinnate immunityreplicationtransmissionviral evolution

Identifiers

PMID42519064
PMCPMC13382436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.