Evidence map›Paper›PMID 42519045›Full record

ArticleiScience2026

Hierarchy of grammar rules for the language of transcriptional activation domains.

David G Cooper, Tamara Y Erkina, Bradley K Broyles, Caleb A Class, Alexandre M Erkine

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David G CooperCollege of Pharmacy and Health Sciences, Butler University, Indianapolis, IN, USA.
Tamara Y ErkinaCollege of Pharmacy and Health Sciences, Butler University, Indianapolis, IN, USA.
Bradley K BroylesCollege of Pharmacy and Health Sciences, Butler University, Indianapolis, IN, USA.
Caleb A ClassCollege of Pharmacy and Health Sciences, Butler University, Indianapolis, IN, USA.
Alexandre M ErkineCollege of Pharmacy and Health Sciences, Butler University, Indianapolis, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcriptional activation domains (ADs) of eukaryotic gene activators have remained enigmatic for decades as short, consensus-less, extremely variable amino acid sequences that lack a specific structure and interact fuzzily with an uncertain number of targets. Understanding AD sequence grammar is critical for solving the enigma. Using rational design of AD sequences and high-throughput

Indexed as

amphipathic α-helixchromatinfuzzy interactionsgene promotergene regulationIDRnucleosometranscriptiontranscription factors

Identifiers

PMID42519045
PMCPMC13382801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.