Evidence map›Paper›PMID 42519044›Full record

ArticleiScience2026

LPA4 in the spinal dorsal horn is a potential therapeutic target for inflammatory pain and neuropathic mechanical hypersensitivity.

Takahisa Shimoda, Simeng Ma, Tomoya Tanaka, Haruto Taniguchi, Kenta Yamamoto, Satoru Yoshikawa, Kazue Hisaoka-Nakashima, Yoki Nakamura, Norimitsu Morioka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takahisa ShimodaDepartment of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Higashihiroshima, Hiroshima, Japan.
Simeng MaDepartment of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Higashihiroshima, Hiroshima, Japan.
Tomoya TanakaDepartment of Research Coordination, Pharmaceuticals Research Center, Asahi Kasei Therapeutics Co. Ltd., 632-1 Mifuku, Izunokuni, Shizuoka 410-2321, Japan.
Haruto TaniguchiDepartment of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Higashihiroshima, Hiroshima, Japan.
Kenta YamamotoDepartment of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Higashihiroshima, Hiroshima, Japan.
Satoru YoshikawaLaboratory for Pharmacology, Pharmaceuticals Research Center, Asahi Kasei Therapeutics Co. Ltd., 632-1 Mifuku, Izunokuni, Shizuoka 410-2321, Japan.
Kazue Hisaoka-NakashimaDepartment of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Higashihiroshima, Hiroshima, Japan.
Yoki NakamuraDepartment of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Higashihiroshima, Hiroshima, Japan.
Norimitsu MoriokaDepartment of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Higashihiroshima, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropathic pain is a major cause of chronic pain, but effective treatments remain limited. To investigate the role of lysophosphatidic acid receptor 4 (LPA4) in pain processing, we generated LPA4-knockout rats and evaluated inflammatory and multiple neuropathic pain models. LPA4 deficiency attenuated second-phase formalin responses and reduced mechanical hypersensitivity in the spared nerve injury and lumbar spinal stenosis models, without affecting baseline locomotor activity or mechanical sensitivity. RNAscope revealed

Indexed as

lysophosphatidic acid receptor 4neuropathic painspinal dorsal horn

Identifiers

PMID42519044
PMCPMC13383862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.