Evidence map›Paper›PMID 42519041›Full record

ArticleiScience2026

Multiomics identifies a prognostic signature and SPIB as a potential regulator of gastric cancer lymph node metastasis.

Zhijie Duan, Keyu He, Dianjie Chen, Lifan Lin, Ming Cao, Shaowei Zhang, Junbo Zhuang, Yintong Zhu, Guodong Shen, Yanfeng Hu

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PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zhijie DuanDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Keyu HeDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Dianjie ChenDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Lifan LinDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Ming CaoDepartment of Surgery, Tongchuan Maternal and Child Health Care Hospital, Tongchuan, Shaanxi 727000, China.
Shaowei ZhangDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Junbo ZhuangDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Yintong ZhuThe First School of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Guodong ShenDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Yanfeng HuDepartment of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The heterogeneity within the same AJCC TNM stage of gastric cancer necessitates robust prognostic biomarkers beyond conventional staging. By integrating transcriptomic data from 1,613 patients across eight cohorts, we developed an 11-gene lymph node metastasis gene signature (LMGS) using an ensemble learning strategy to overcome the instability of traditional models. LMGS robustly predicted survival (mean C-index = 0.619), providing incremental prognostic value beyond conventional AJCC staging. Single-cell and spatial transcriptomic analyses revealed LMGS enrichment in epithelial/immune cells at the tumor-normal interface. Integrative analysis nominated the transcription factor SPIB as a candidate regulator, which was specifically overexpressed in metastatic lesions. Our study provides a clinically relevant prognostic tool and identifies SPIB as a molecular marker associated with lymphatic dissemination.

Indexed as

biomarkergastric cancerlymph node metastasismachine learningprognostic modeltumor heterogeneity

Identifiers

PMID42519041
PMCPMC13383869

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.