Evidence map›Paper›PMID 42519026›Full record

ArticleiScience2026

TMEM97 regulates cholesterol biosynthesis and mitochondrial metabolism in gastric carcinoma.

Saniye Koç Ada, Yahya Yozbatıran, Bengü Yaren Beyaz, Ceren Sarı, Elif Gelenli Dolanbay, Halil İbrahim Saygı, Ceren Sümer, Cyrille Mesue Njume, Ali Çakmak, Fatma Zehra Sarı and 4 more

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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Saniye Koç AdaScience and Advanced Technologies Research Center (BILTAM), Istanbul Medeniyet University, Istanbul 34700, Türkiye.
Yahya YozbatıranScience and Advanced Technologies Research Center (BILTAM), Istanbul Medeniyet University, Istanbul 34700, Türkiye.
Bengü Yaren BeyazTürkiye Cancer Institute, Health Institutes of Turkiye (TUSEB), Istanbul 34718, Türkiye.
Ceren SarıTürkiye Cancer Institute, Health Institutes of Turkiye (TUSEB), Istanbul 34718, Türkiye.
Elif Gelenli DolanbayDepartment of Histology and Embryology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul 34700, Türkiye.
Halil İbrahim SaygıDepartment of Histology and Embryology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul 34700, Türkiye.
Ceren SümerTürkiye Cancer Institute, Health Institutes of Turkiye (TUSEB), Istanbul 34718, Türkiye.
Cyrille Mesue NjumeDepartment of Computer Engineering, Ayazaga Campus, Istanbul Technical University, Istanbul 34469, Türkiye.
Ali ÇakmakDepartment of Computer Engineering, Ayazaga Campus, Istanbul Technical University, Istanbul 34469, Türkiye.
Fatma Zehra SarıTürkiye Health Data Research and Artificial Intelligence Applications Institute, Health Institutes of Türkiye (TUSEB), Istanbul 34718, Türkiye.
Şeyma ÇimenRegenerative and Restorative Medicine Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul 34810, Türkiye.
Mertkaya ArasTürkiye Cancer Institute, Health Institutes of Turkiye (TUSEB), Istanbul 34718, Türkiye.
Andaç KılıçkapDepartment of Medical Biochemistry, Faculty of Medicine, Istanbul Medeniyet University, Istanbul 34700, Türkiye.
Burcu YücelScience and Advanced Technologies Research Center (BILTAM), Istanbul Medeniyet University, Istanbul 34700, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells regulate cholesterol levels to sustain proliferation and metabolic adaptation. Here, we show that TMEM97 coordinates cholesterol sensing with oxidative phosphorylation in gastric cancer. Loss of TMEM97 reduced

Indexed as

CARC/CRACcholesterol biosynthesismetabolic reprogrammingmitochondrial bioenergeticsoxidative phosphorylationTMEM97

Identifiers

PMID42519026
PMCPMC13382799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.