ArticleiScience2026
Structural insights on the ligand selectivity of the mouse trace amine-associated receptor TAAR7e.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Trace amine-associated receptors (TAARs), a G-protein-coupled receptor subclass detecting volatile amines, are co-expressed with odorant receptors in the main olfactory epithelium. While many behaviorally relevant amines are known for olfactory TAARs, the molecular basis of their selectivity for amines of varying lengths and primary/tertiary amines remains unclear. Using mTAAR7e as a model, we combined cAMP accumulation luciferase assays and computational simulations to investigate this issue. Molecular dynamics (MD) simulations and structure-activity relationship analysis established a clear preference for medium-chain, tertiary amines. Optimal steric complementarity within the binding pocket dictates the preference for medium-length alkyl chains like DMHA and DMOA. Site-directed mutagenesis further confirmed the essential role of Asp127
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