Evidence map›Paper›PMID 42519017›Full record

ArticleiScience2026

Sleep differentially modulates synaptic vesicle protein 2A and spine density across cortical regions and development.

Jing Ma, Alexandra Braun, Angela Oskamp, Lena Kricsfalussy-Hrabár, Nadja Hermes, Salma Djakkani, Ulrike Holz, Sabine Jakobs, Sabina Klein, Stefan Stüsgen and 8 more

Abstract read
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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jing MaInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Alexandra BraunInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Angela OskampInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Lena Kricsfalussy-HrabárInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Nadja HermesInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Salma DjakkaniInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Ulrike HolzInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Sabine JakobsInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Sabina KleinInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Stefan StüsgenInstitute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich, Jülich, Germany.
Philipp KrapfInstitute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich, Jülich, Germany.
Bernd NeumaierInstitute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Jülich, Jülich, Germany.
Alexander DrzezgaInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Simone BeerInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Andreas BauerInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.
Astrid RollenhagenJARA BRAIN, Institute of Neuroscience and Medicine (INM-10), Forschungszentrum Jülich, Jülich, Germany.
Björn KampaSystems Neurophysiology, Institute of Zoology, RWTH Aachen University, Aachen, Germany.
David ElmenhorstInstitute of Neurosciences and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep is proposed to regulate synaptic strength; yet, the underlying mechanisms remain debated under the synaptic homeostasis hypothesis (SHY). We examined synaptic vesicle glycoprotein 2A (SV2A) and dendritic spine density in mouse brain across conditions of physiological sleep and sleep deprivation. Spine density decreased during sleep and increased following sleep deprivation, consistent with the SHY. In contrast, [

Indexed as

dendritic spinesPET imagingsleepsleep deprivationSV2Asynaptic plasticity

Identifiers

PMID42519017
PMCPMC13383866

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.