Interactions between minimal amount of exercise and low-density lipoprotein cholesterol on incident dementia after stroke.

Li-Wei Hong, Hung-Hsuan Chiu, Pai-Yi Chiu, Yao-Chin Wang, Hsien Chang Yeh, Woon-Man Kung

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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Li-Wei HongDivision of Neurosurgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.

Hung-Hsuan ChiuDepartment of Neurology, China Medical University Hospital, Taichung 40402, Taiwan.

Pai-Yi ChiuDepartment of Neurology, Show Chwan Memorial Hospital, Changhua 500, Taiwan.

Yao-Chin WangGraduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan.

Hsien Chang YehSchool of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.

Woon-Man KungDivision of Neurosurgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive impairment often follows stroke. Regular physical activity has been shown to be associated with reduced dementia risk, while the association with low-density lipoprotein cholesterol (LDL-C) is still not clear. We examined the association of minimal amount of exercise (MAE) and LDL-C with incident dementia after stroke. A retrospective cohort study was conducted using the History-Based Artificial Intelligence Clinical Diagnosis of Dementia Syndrome project, including adults aged 50 years or older with stroke from three medical centers in Taiwan. MAE and LDL-C were used to classify individuals. Among 679 post-stroke individuals without dementia at baseline, exercise was associated with better cognitive and functional status. Dementia progression was highest in the low LDL-C/no exercise group and lowest in the high LDL-C/exercise group. Regular MAE, not too low LDL-C levels (≥100 mg/dL), or both combined, were associated with a lower risk of progression to incident dementia.

Indexed as

incident dementialow-density lipoprotein cholesterolminimal amount of exercisestroke

Identifiers

PMID42519014

DOI10.1016/j.isci.2026.116806

PMCPMC13382148

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