Evidence map›Paper›PMID 42518920›Full record

ArticleThe Lancet regional health. Southeast Asia2026

Clinical characteristics of nontuberculous mycobacterial infections among people with presumptive tuberculosis in India: a multicenter study (2021-2025).

Surendra Kumar Sharma, Vishwanath Upadhyay, Alladi Mohan, Ravindra Kumar Dewan, Rajesh Solanki, Kamal Kishore Chopra, Babaji Ghewade, Digambar Behera, Ravindra Mohan Pandey, Ajoy Kumar Verma and 12 more

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Article in The Lancet regional health. Southeast Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Surendra Kumar SharmaDepartment of Molecular Medicine, Jamia Hamdard (Deemed to be University), New Delhi, India.
Vishwanath UpadhyayDepartment of Molecular Medicine, Jamia Hamdard (Deemed to be University), New Delhi, India.
Alladi MohanDepartment of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Ravindra Kumar DewanDepartment of Thoracic Surgery, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Rajesh SolankiDepartment of Pulmonary Medicine, BJ Medical College, Ahmedabad, Gujarat, India.
Kamal Kishore ChopraIntermediate Reference Laboratory, New Delhi TB Centre, New Delhi, India.
Babaji GhewadeDepartment of Respiratory Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research (Deemed to be University), Wardha, Maharashtra, India.
Digambar BeheraDepartment of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ravindra Mohan PandeyFormer Professor, Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Ajoy Kumar VermaDepartment of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Ashish RanjanDepartment of Respiratory Critical Care, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Raj Narayan YadavDepartment of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Kaushal Kumar DwivediIntermediate Reference Laboratory, New Delhi TB Centre, New Delhi, India.
Pranav PatelIntermediate Reference Laboratory, State TB Demonstration Centre, BJ Medical College, Ahmedabad, Gujarat, India.
Rangineni JayapradaDepartment of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Kusum SharmaDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Jay BhanushaliDepartment of Respiratory Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research (Deemed to be University), Wardha, Maharashtra, India.
Dhruminkishan PrajapatiDepartment of Pulmonary Medicine, BJ Medical College, Ahmedabad, Gujarat, India.
Mahmud HanifIntermediate Reference Laboratory, New Delhi TB Centre, New Delhi, India.
Monica PatelIntermediate Reference Laboratory, State TB Demonstration Centre, BJ Medical College, Ahmedabad, Gujarat, India.
Manjula SinghDepartment of Delivery Research, Indian Council of Medical Research, New Delhi, India.
Seyed Ehtesham HasnainDepartment of Life Science, Sharda University, Greater Noida, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Disease caused by nontuberculous mycobacteria (NTM) is often misdiagnosed as tuberculosis (TB) in India. Comprehensive studies on NTM are lacking, therefore, the present study aimed to describe clinical features, underlying conditions, species distribution, and treatment outcomes of NTM disease among people with presumptive TB (individuals with symptoms suggestive of TB) in India. Methods: This prospective study (2021-2025) was conducted across seven tertiary care centres in India. People older than or equal to 12 years, irrespective of their human immunodeficiency virus status, diagnosed with NTM disease were included. Individuals with concurrent TB were excluded. Participants were recruited consecutively from individuals with presumptive pulmonary TB (PTB) and extrapulmonary TB at participating centres. Clinical, radiological, and laboratory data were collected from study centres under supervision of dedicated clinicians. Line probe assay (LPA) and Whole-genome sequencing (WGS) were used for NTM diagnosis. Recent guideline-based treatment (GBT) was administered to people diagnosed with NTM disease. Main outcomes of this study included clinical and radiological characteristics, species distribution, and treatment outcomes of NTM pulmonary disease (NTM-PD) and extrapulmonary NTM (EP-NTM) disease. Findings: Among 71,143 individuals with presumptive TB, 230 (0·32%) had NTM disease (191 pulmonary and 39 extrapulmonary). In NTM-PD, common underlying conditions included previous PTB (80·6%), malnutrition (47·1%), and vitamin D deficiency (43·5%). Interpretation: NTM disease among people with presumptive TB is an emerging public health problem in India. Integrating rapid molecular diagnostic tests for early diagnosis and GBT into National Tuberculosis Programmes is essential to improve outcomes by reducing diagnostic and treatment delays. Funding: Indian Council of Medical Research.

Indexed as

clinical conditionsDiagnosisEpidemiologyExtrapulmonary diseaseGeographic VariationIndiaNontuberculous mycobacteriaOutcomePulmonary diseaseTreatment

Identifiers

PMID42518920
PMCPMC13382146

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