ArticlePsychoradiology2026
White matter functional connectome topology and its clinical correlations in adolescent major depressive disorder.
Article in Psychoradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adolescence is a critical period for brain network remodeling and the onset of major depressive disorder (MDD); however, white matter (WM) functional topology in adolescent MDD remains underexplored. Given that WM functional signals reflect meaningful neural activity and are disrupted in psychiatric disorders, this study aimed to characterize WM functional connectome alterations in adolescents with MDD and examine their clinical associations. Methods: Resting-state fMRI data were obtained from a cohort of adolescents with MDD ( Results: Compared with HCs, adolescent MDD exhibited significant reductions in the clustering coefficient, characteristic path length, and local efficiency. CCA identified distinct covariation patterns: reduced global integration was linked to severe suicidal ideation and depressed mood, while impaired local segregation was associated with vegetative symptoms such as weight loss and insomnia. Subgroup analyses revealed significant sexual dimorphism, with male patients demonstrating more severe topological impairments than females. A similar pattern was observed in the independent replication cohort. The classification analysis achieved above-chance accuracy (69.6 and 60% in the two cohorts). Conclusions: Our results reveal a topologically shifted WM functional connectome structure in adolescent MDD, providing new clues to aid in understanding the pathophysiology of its pathophysiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.