ArticleClinical, cosmetic and investigational dermatology2026
Remodeling Effect of HA Hybrid Cooperative Complexes on Dermal White Adipose Tissue and Its Structure.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
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Abstract
Purpose: Skin aging affects white adipose tissue, resulting in volume loss and appearance of deep wrinkles. This study aimed to investigate the effects of Profhilo Animals and Methods: 15 SHK-1 female mice were used in this study. Six mice were treated with the medical device and nine were used as control group. Each mouse received two consecutive subcutaneous injections, 15 days apart. Two months after the first injection, all animals were sacrificed, and two sites/mouse were sampled. Through Western blot or immunofluorescence analysis, the protein expression levels of PPARγ, Caveolin1, Perilpin1 and Collagen VI were monitored. Using image analysis, the number, diameter, and area of dWAT adipocytes and also the tissue compactness were compared between the two experimental groups. Results: Image analysis revealed that the distribution of adipocytes based on diameter was different between the two groups, with a greater number of "very large" adipocytes in the treated group compared to the control; consequently, the measure of the total dWAT area was higher in the group treated with the medical device. In parallel, the expression levels of Collagen VI and PPARγ were also higher in the treated group. In addition, the group treated with the medical device showed a higher degree of tissue compactness than the control group. Conclusion: Profhilo
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