ArticleFrontiers in oncology2026
Incremental diagnostic value of MRI PI-RADS classification combined with PSA density for prostate cancer.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the incremental diagnostic value of magnetic resonance imaging Prostate Imaging Reporting and Data System (PI-RADS) score combined with prostate-specific antigen density (PSAD) for prostate cancer (PCa), and to evaluate the clinical implications of different combined strategies. Methods: A total of 187 patients who underwent prostate MRI and had pathological results were retrospectively included, including 117 with PCa and 70 with benign prostatic hyperplasia. Univariate and multivariate logistic regression analyses were performed. A PI-RADS-only model, a log(PSAD)-only model, a combined model, and an adjusted model were constructed. Receiver operating characteristic curves and DeLong tests were used to evaluate diagnostic performance. Results: Age, log(tPSA), f/t ratio, log(PSAD), and PI-RADS score were all significantly associated with PCa diagnosis (all Conclusion: PI-RADS combined with PSAD improves diagnostic discrimination for PCa and may support different clinical strategies requiring higher specificity or sensitivity.
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