Evidence map›Paper›PMID 42518775›Full record

ArticleFrontiers in human neuroscience2026

Developmental stability of task-rest neural efficiency in youth using a threat and cognitive control task.

Parmis Khosravi, Julia O Linke, Anjali D Poe, Chase Antonacci, Reut Naim, Elise Cardinale, Katharina Kircanski, Anderson Winkler, Nathan Fox, Daniel S Pine and 1 more

Abstract read
In one paragraph

Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Parmis KhosraviEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Julia O LinkeDepartment of Psychology, Johannes-Gutenberg University, Mainz, Germany.
Anjali D PoeDepartment of Psychology, Stony Brook University, Stony Brook, NY, United States.
Chase AntonacciDepartment of Psychology, Stanford University, Stanford, CA, United States.
Reut NaimSchool of Psychological Sciences, Tel-Aviv University, Tel Aviv-Yafo, Israel.
Elise CardinaleDepartment of Psychology, Catholic University of America, Washington, DC, United States.
Katharina KircanskiDepartment of Psychology, University of Southern California, Los Angeles, CA, United States.
Anderson WinklerDivision of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United States.
Nathan FoxDepartment of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, United States.
Daniel S PineEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Simone P HallerEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.

Funding

Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
Trajectories of Behavioral Inibition and Risk for AnxietyU01MH093349 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A · 2011 to 2020
$6.6M
Affect &Cerebral Asymmetry: A Developmental ApproachR37HD017899 · NICHD · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A · 2001 to 2010
$5.6M
AFFECT AND CEREBRAL ASYMMETRY: A DEVELOPMENTAL APPROACHR01HD017899 · NICHD · UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS · PI FOX, NATHAN A · 1985 to 2000
$284k
Intramural NIH HHS ZIA MH002782NICHD NIH HHS R01 HD017899NICHD NIH HHS R37 HD017899NIMH NIH HHS U01 MH093349
6 · The paper itself

Abstract

Behaviors arise from coordinated neural activity across diverse spatial and temporal scales. Prior work has linked better task performance and cognitive functioning to patterns of global network connectivity requiring minimal reconfiguration when switching between task demands. This metric indexing similarity in functional connectivity across task and rest has been termed "neural efficiency." Here we assess stability of neural efficiency over approximately 3 years in adolescence, specificity across two task-rest combinations and associations with anxiety. At approximately age 16 and/or 19, 95 participants completed a resting state scan alongside a cognitive control and/or threat task. Neural efficiency was quantified as partial correlations between intrinsic and task-related functional connectivity patterns across the whole brain. We tested temporal stability across the three-year interval, as well as associations with task performance and anxiety across the two task-rest combinations at the two time points. Neural efficiency values remained relatively stable from mid to late adolescence (ICC[3,1] = 0.51-0.58). The cognitive control task showed higher values than the threat task. Across tasks, neural efficiency was associated with better performance (i.e., reduced interference), although not consistently (

Indexed as

children and adolescentscognitive controlfMRIneural efficiencyresting statethreat processing

Identifiers

PMID42518775
PMCPMC13381436

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.