ArticleJournal of oral biology and craniofacial research
Comparative evaluation of intralesional platelet-rich plasma and triamcinolone in management of oral submucous fibrosis: A prospective clinical study.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oral Submucous Fibrosis (OSMF) is a chronic, progressive, potentially malignant disorder characterized by fibrosis of the oral mucosa, resulting in restricted mouth opening, burning sensation, mucosal blanching, and reduced cheek flexibility. Effective management remains challenging, and newer regenerative therapies such as platelet-rich plasma (PRP) have shown promising results. Aim: To compare the efficacy of intralesional PRP and triamcinolone acetonide in improving mouth opening, burning sensation, cheek flexibility, and mucosal colour in patients with OSMF. Materials and methods: This prospective comparative clinical study included 30 patients with OSMF (Group I-III according to the Ranganathan classification). Participants were randomly allocated into two groups of 15 each. Group I received intralesional PRP prepared using a standardized double-spin centrifugation technique, while Group II received intralesional triamcinolone acetonide. Six weekly injections were administered along with adjunct physiotherapy. Clinical parameters were assessed at baseline, 1 week, 6 weeks, and 3 months. Statistical analysis included two-way mixed ANOVA, Friedman test, Mann-Whitney Results: Both groups demonstrated significant improvement in all clinical parameters (p < 0.001). No significant intergroup difference was observed in mouth opening. PRP showed significantly greater reduction in burning sensation at 3 months (p < 0.001) and superior improvement in mucosal colour, whereas triamcinolone demonstrated greater improvement in cheek flexibility (p < 0.05). Conclusion: Both PRP and triamcinolone acetonide were effective in the management of OSMF. PRP provided superior symptomatic relief and mucosal improvement, whereas triamcinolone demonstrated greater improvement in cheek flexibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.